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BIS(GLYCERYL DIMETHACRYLATE) PYROMELLITATE.

Optional CAS 148019-46-9 / NAIL CONDITIONING

A high-performance adhesion-promoting monomer engineered specifically for advanced nail technologies. It utilizes a complex pyromellitate structure to create a resilient, flexible bridge between the natural nail plate and synthetic coatings.

Nail conditioning Adhesion promotion Film formation

Science

The molecule features four methacrylate groups and dual carboxylic acid groups, enabling it to establish robust covalent and hydrogen bonds with nail keratin. Upon UV/LED exposure, it undergoes controlled polymerization to form a durable film that enhances product longevity and structural integrity.


Research

Medium confidence
Effective range 0.56–10%
Optimal

0.56%

Key findings

  1. 01 Demonstrated significant improvement in basecoat adhesion to the natural nail without inducing immediate plate dystrophy.

Transparency

Not commonly dusted
Min. effective
0.5%
Red flag below
0.1%

While effective at low concentrations (~0.5%), the specialized nature of this monomer means it is rarely used in standard skincare, making its presence in non-nail products a likely red flag for 'label dusting'.


The Formula

Solubility
Oil
Optimal pH 6.5 – 7
0 7 14

Stability

Highly reactive; requires opaque packaging and the addition of stabilizers like p-hydroxyanisole to prevent premature polymerization triggered by heat or UV light.

Synergies

  • Methacrylate esters
  • Photoinitiators
  • Keratin-binding agents

Conflicts

  • Strong oxidizers
  • Free radical initiators
  • UV radiation
  • Excessive heat
  • Moisture

Safety

CIR Status
Safe as used
Max tested
10%
Sensitization risk High

Safe for nail applications provided strict avoidance of skin contact. As a Category 1 sensitizer, it may cause allergic contact dermatitis or eye irritation if mishandled.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Optional

A precision-engineered adhesive monomer for professional nail systems that requires expert formulation to mitigate its high sensitization potential.


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