Science
Mechanism of Action
It operates as a sodium channel modulator, specifically prolonging the open state of voltage-gated sodium channels within nerve membranes. In humans, topical exposure may trigger paresthesia—characterized by tingling or burning sensations—due to the involuntary stimulation of sensory nerve endings.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Hoellinger et al. (1987) observed potential genotoxicity in animal bone marrow following extreme dermal gavage doses of 1000 mg/kg.
- 02 WHO technical reports indicate that 2% aerosol concentrations used for aircraft disinsection do not present a toxic hazard to humans under standard exposure.
Transparency
Dusting Analysis
This ingredient is strictly a pesticide and is not permitted in cosmetic formulations; therefore, 'dusting' is not applicable as its inclusion would constitute a regulatory violation.
The Formula
Formulation
Stability
Highly sensitive to ultraviolet light and atmospheric oxidation. While stable in acidic to neutral ranges, it undergoes rapid hydrolysis in alkaline environments (pH > 7.0).
Synergies
- Piperonyl butoxide (UV stabilizer)
Conflicts
- Alkaline ingredients
- Strong oxidizing agents
- UV light
Safety
Safety Profile
Bioresmethrin is not approved for cosmetic use in the EU (Reg. EC No 1107/2009) and has been voluntarily withdrawn from US registration. It is highly toxic to aquatic ecosystems.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Bioresmethrin is an industrial-grade insecticide with no clinical justification for skincare use and is legally restricted from cosmetic formulations.
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