Science
Mechanism of Action
It upregulates critical physical barrier genes, including Filaggrin (FLG) and Loricrin (LOR), while enhancing cellular hydration via Aquaporin-3 (AQP3). Furthermore, it provides dual-action protection by scavenging free radicals and inhibiting collagen-degrading enzymes like MMP-1 and elastase, while stimulating Type 1 pro-collagen synthesis.
Research
Clinical Evidence
High confidence5%
Key findings
- 01 A 2023 clinical assessment demonstrated that 1.0% concentration reduced trans-epidermal water loss (TEWL) by 20.62% and decreased skin redness by 21.01% over 28 days.
- 02 Research published in MDPI (2023) confirmed a 55.10% inhibition of elastase at a concentration of 100 μg/mL, indicating significant anti-wrinkle potential.
- 03 A 10.0% concentration was clinically verified in primary irritation tests as non-sensitizing and safer than non-fermented counterparts.
Transparency
Dusting Analysis
Because measurable clinical benefits—such as a 20% reduction in TEWL—occur at just 1.0%, many formulations use it at this effective threshold. However, concentrations below 0.5% may be insufficient for achieving the claimed anti-aging and barrier-repair benefits.
The Formula
Formulation
Stability
Stable in standard skincare pH ranges (4.5–7.0). It is heat-sensitive and should not be exposed to temperatures exceeding 40°C during the manufacturing process to preserve metabolic activity.
Synergies
- Niacinamide
- Ceramides
- Hyaluronic Acid
- Peptides
Conflicts
- Strong oxidizing agents
Safety
Safety Profile
The CIR Expert Panel considers fermented Panax ginseng safe for topical application. Fermentation specifically reduces the toxicological potency often associated with raw botanical extracts.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A sophisticated probiotic-botanical hybrid that delivers scientifically backed improvements in barrier resilience and skin elasticity at relatively low inclusion rates.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources