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BETA-SANTALYL BUTYRATE.

Optional CAS 67633-98-1 / PERFUMING

A refined ester derivative of sandalwood, Beta-Santalyl Butyrate serves as a sophisticated aromatic agent that provides a clean, woody profile. Beyond its masking capabilities, it functions as a skin-conditioning ester that undergoes enzymatic conversion upon application to release beneficial sandalwood alcohols.

Perfuming Masking Skin conditioning

Science

Upon topical application, skin esterases hydrolyze this molecule into beta-santalol and butyric acid. The resulting santalol components are recognized for their secondary biological activities, including mild antimicrobial support and potential anti-inflammatory properties that help maintain skin equilibrium.


Research

Low confidence
Effective range 0.1–1%
Optimal

0.5%

Key findings

  1. 01 Research indicates that related santalol compounds at higher concentrations (5%) exhibit significant chemopreventive properties against UVB-induced cellular stress and inhibit the enzymatic pathways associated with epidermal tumor development in vivo.

Transparency

Commonly dusted
Min. effective
0.05%
Red flag below
0.01%

Because it is primarily categorized as a fragrance or masking agent, many formulations use it at infinitesimal concentrations purely for scent, rather than at levels where the skin-conditioning benefits of its hydrolyzed components could be realized.


The Formula

Solubility
Oil
Optimal pH 4.5 – 7
0 7 14

Stability

The ingredient is most stable in slightly acidic to neutral environments; extreme pH levels will cause the ester bond to break down prematurely in the bottle rather than on the skin.

Synergies

  • Tocopherol
  • Sandalwood oil derivatives
  • Lipid-based delivery systems

Conflicts

  • Strong oxidizing agents
  • Strongly acidic exfoliants
  • Highly alkaline surfactants

Safety

CIR Status
Not reviewed
Max tested
1%
Pregnancy
Safe
Sensitization risk Low

While not listed as a mandatory EU allergen, it is subject to industry-standard concentration limits for leave-on products to ensure maximum skin tolerance.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Optional

An elegant, low-irritancy masking agent that offers potential secondary skin-soothing benefits via its sandalwood-related metabolites.


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References