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Moumoujus

BENZYLSULFONYLSERYLGLYCINE AMIDINOBENZAMIDE ACETATE.

Valuable CAS 866428-02-6 / SKIN CONDITIONING

A high-precision synthetic peptide derivative engineered to stabilize the skin's surface by regulating specific enzymatic activities. It acts as a sophisticated barrier-balancing agent that synchronizes the epidermal microbiome and structural proteins for resilient, hydrated skin.

Summary

barrier repair serine protease inhibitor microbiome regulator humectant skin conditioner

Science

Mechanism of Action

This ingredient functions as a targeted serine protease inhibitor, specifically modulating the overactivity of urokinase and plasmin in the epidermis. By inhibiting these enzymes, it prevents the premature degradation of corneodesmosomes—specifically Desmoglein 1—while simultaneously upregulating the production of essential barrier proteins like loricrin and transglutaminase-1 to physically reinforce the skin's architecture.

Research

Clinical Evidence

High confidence
Effective range 1–1%
Optimal

1%

Key findings

  1. 01 In vivo testing at 1% concentration demonstrated a 16% reduction in transepidermal water loss (TEWL) on dry cheek skin within 7 days.
  2. 02 In vitro data shows up to 97% inhibition of urokinase activity and a 41% reduction in plasmin activity, critical for preventing barrier breakdown.
  3. 03 Clinical microbiome analysis confirmed a shift toward healthy skin flora, specifically increasing Staphylococcus epidermidis while reducing populations of Corynebacterium kroppenstedtii.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
1%
Red flag below
0.2%

As a high-tech trade name peptide (SYN-UP), this ingredient is often included at sub-clinical levels for label claims. Formulations containing significantly less than 1% of the trade name solution may not deliver the measured 16% barrier improvement or microbiome-balancing benefits.

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 7
0 7 14

Stability

Maintains high stability across a broad pH range, with peak biological activity observed at pH 6.0. It is typically supplied in a glycerin-water base for easier integration.

Synergies

  • Glycerin
  • Barrier-identical lipids
  • Niacinamide

Conflicts

  • Strong oxidizing agents
  • Proteolytic enzymes
  • Formulations with pH below 3.0 or above 8.0

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
1%
Pregnancy
Safe
Sensitization risk Low

Recognized as a safe skin-conditioning agent in the EU CosIng and PCPC databases; it is notably effective at reducing sensory irritation (stinging) in sensitive skin types.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

An exceptional biotech peptide for those requiring pharmaceutical-grade barrier reinforcement and microbiome stabilization, provided it is used at the 1% clinical threshold.

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