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BENZYL ISOEUGENOL.

Optional CAS 120-11-6 / PERFUMING

A sophisticated synthetic aromatic ether that serves as both a fragrance fixative and an auxiliary skin-conditioning agent. It is valued in high-performance formulations for its superior oxidative stability compared to traditional phenols like eugenol, ensuring long-lasting olfactory and structural integrity.

Perfuming Fragrance Fixative Antioxidant Antimicrobial

Science

Beyond its aromatic properties, this molecule functions as a lipid-soluble antioxidant that scavenges free radicals and provides secondary antimicrobial protection by destabilizing microbial cell membranes. Emergent research indicates it may also modulate melanin production through potential tyrosinase inhibition.


Research

Medium confidence
Effective range 0.4–1%
Optimal

1%

Key findings

  1. 01 Established as the No Expected Sensitization Induction Level (NESIL) via QRA2 modeling.
  2. 02 Determined as the maximum concentration in fine fragrances to optimize odor profile while mitigating sensitization risk.

Transparency

Commonly dusted
Min. effective
0.1%
Red flag below
0.05%

Because it is primarily a fragrance fixative, it is often included at minute levels (below 0.1%) simply to mask base odors rather than to provide the antimicrobial or antioxidant benefits observed at higher concentrations.


The Formula

Solubility
Oil
Optimal pH 3 – 12
0 7 14

Stability

Highly resilient ether structure that resists discoloration and degradation even in extreme pH environments like alkaline soaps. It is significantly more stable than its parent compounds, isoeugenol and eugenol.

Synergies

  • Isopropyl Myristate (IPM)
  • Triethyl Citrate (TEC)

Conflicts

  • Strong oxidizing agents
  • Dipropylene Glycol (as primary solvent)

Safety

CIR Status
Not reviewed
Max tested
1%
Pregnancy
Safe
Sensitization risk Moderate

Classified as a Category 1 skin sensitizer; use is strictly regulated by IFRA. While safe up to 1.0% in leave-on face creams, concentration must be carefully monitored to avoid contact dermatitis.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Optional

A high-stability aromatic fixative with secondary antioxidant benefits, though its potential for sensitization requires precise concentration controls.


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