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Moumoujus

BENZOXONIUM CHLORIDE.

Valuable CAS 19379-90-9 / ANTIMICROBIAL

A potent quaternary ammonium compound primarily utilized for its broad-spectrum antiseptic and antimicrobial properties. In skincare and topical applications, it serves as a highly effective agent for purifying the skin surface and stabilizing formulations against microbial contamination.

Summary

Antimicrobial Antiseptic Preservative Cationic Surfactant

Science

Mechanism of Action

Functioning as a cationic surfactant, the molecule carries a positive charge that electrostatically targets the negatively charged membranes of microorganisms. Upon contact, it penetrates the lipid bilayer, causing structural disruption and leakage of cellular components, effectively neutralizing bacteria and fungi through cell lysis.

Research

Clinical Evidence

Medium confidence
Effective range 0.1–0.2%
Optimal

0.1%

Key findings

  1. 01 A 0.1% concentration used in conjunction with tioxolone demonstrated significant clinical efficacy with high patient compliance and a favorable safety profile compared to traditional invasive treatments.
  2. 02 Clinical diagnostic evaluations identified the ingredient as a potential allergen in specific antiseptic sprays, capable of inducing acute eczematous reactions in sensitized individuals at a 0.1% concentration.

Transparency

Dusting Analysis

Not commonly dusted
Min. effective
0.05%
Red flag below
0.01%

Because it is primarily regulated as a medicinal active or a biocide, it is rarely 'dusted' for marketing purposes in standard cosmetics. However, any concentration below 0.05% may fail to provide the requisite antimicrobial protection intended for active treatment products.

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 10
0 7 14

Stability

Exhibits exceptional thermal and chemical stability; it remains active even after autoclaving. While stable across a wide pH range, its antimicrobial performance is maximized near a neutral pH of 7.0.

Synergies

  • Tioxolone
  • Non-ionic surfactants
  • Alcohol-based carriers

Conflicts

  • Anionic surfactants
  • Soaps
  • Nitrates
  • Silver salts
  • Citrates
  • Aluminum

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0.2%
Sensitization risk Moderate

Regulated in the EU and Switzerland up to 0.2% in topical antiseptics. It is recognized as a skin and eye irritant in its concentrated raw form and has been documented as a contact allergen in specific populations.

Your Skin

Skin Compatibility

Yes Normal
No Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Low

Our Assessment

Verdict

Valuable

A high-precision antimicrobial agent best suited for targeted corrective treatments, though its potential for sensitization requires careful formulation and patch testing.

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References

Sources