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BENZOPHENONE-6.

Optional CAS 131-54-4 / FRAGRANCE, UV ABSORBER

Benzophenone-6 is a specialized oil-soluble UV absorber utilized primarily to maintain the integrity of cosmetic formulations against light-induced degradation. By neutralizing radiation in the 290–400 nm spectrum, it ensures that active ingredients, pigments, and fragrances remain stable and effective throughout their shelf life.

UV Absorber Light Stabilizer Penetration Enhancer

Science

This molecule acts as a photostabilizer by intercepting ultraviolet energy and converting it into low-level thermal energy, which is then safely dissipated. Beyond its role as a light shield, it serves as a secondary penetration enhancer, subtly improving the delivery of lipophilic actives into the skin's lipid barrier.


Research

Medium confidence
Effective range 0.1–1%
Optimal

0.5%

Key findings

  1. 01 In vitro Ames testing (2021) indicated potential mutagenic activity in isolated bacterial strains without metabolic activation, though safety was confirmed in the presence of S9 activation.
  2. 02 CIR safety assessments (1983/2020) validated the ingredient as non-sensitizing and non-irritating to human skin even at 100% concentration.

Transparency

Not commonly dusted
Min. effective
0.05%
Red flag below
0.01%

Because it is used to protect the formula rather than treat the skin, 'dusting' is less of a concern. However, concentrations below 0.05% may be insufficient to provide meaningful product stability in clear packaging.


The Formula

Solubility
Oil
Optimal pH 6 – 8.5
0 7 14

Stability

Highly photostable and heat-resistant; however, it shows vulnerability in strongly acidic environments (pH < 5.0) where it may react slowly.

Synergies

  • Lipophilic antioxidants
  • Oil-soluble fragrances
  • Organic UV filters

Conflicts

  • Strong oxidizing agents
  • Strongly acidic solutions

Safety

CIR Status
Safe as used
Max tested
1%
Sensitization risk Low

While safe for topical use, it is regulated as a stabilizer rather than a primary sunscreen active in the EU and USA. It is not an approved UV filter for SPF claims.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Optional

A valuable secondary additive for protecting product aesthetics and stability, though it offers no primary therapeutic benefit to the skin.


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References