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Moumoujus

BASIC RED 2.

Avoid CAS 477-73-6 / HAIR DYEING

A cationic lipophilic dye traditionally utilized as a biological stain and industrial colorant. Within the context of precision skincare, it serves no therapeutic function and is primarily identified as a hazardous substance prohibited in several global cosmetic markets.

Summary

colorant

Science

Mechanism of Action

It operates through electrostatic interaction, where the positively charged (cationic) molecules of the dye bind to negatively charged structures, specifically nucleic acids like DNA and RNA, as well as acidic protein residues found in keratinized skin and hair tissues.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Concentrations of 0.25% are utilized in histology for Gram-negative bacteria counterstaining, with no recorded therapeutic efficacy for dermatological conditions.
  2. 02 QSAR modeling and preliminary animal data indicate potential risks of genotoxicity and systemic carcinogenicity.

Transparency

Dusting Analysis

Not commonly dusted
Red flag below
0.001%

Given its prohibition in the European Union and its potential for genotoxicity, any inclusion of Basic Red 2 in a topical formulation—even at trace levels—is a significant safety violation.

The Formula

Formulation

Solubility
Water
Optimal pH 4 – 9
0 7 14

Stability

The molecule is highly stable in acidic to neutral ranges but is exceptionally light-sensitive, requiring light-protected storage. It precipitates when encountering strong bases.

Conflicts

  • Anionic surfactants
  • Strong oxidizing agents
  • Sodium hydroxide
  • Strong bases

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
0%
Pregnancy
Caution
Sensitization risk High

Listed under Annex II of Regulation (EC) No 1223/2009 as a prohibited substance. Classified as H315 (Skin Irritation) and H318 (Serious Eye Damage).

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Low

Our Assessment

Verdict

Avoid

An industrial colorant with a 'worst' safety profile that offers zero clinical benefit and poses significant risks for irritation and systemic toxicity.

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