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BASIC GREEN 4.

Avoid CAS 569-64-2 / HAIR DYEING

A synthetic cationic triphenylmethane dye primarily utilized as a colorant in semi-permanent hair care and specialized biological staining. Due to significant regulatory restrictions and potential cellular toxicity, it is not a standard ingredient in modern therapeutic skincare formulations.

colorant

Science

As a cationic (positively charged) molecule, it binds via electrostatic attraction to negatively charged proteins on the hair shaft and skin surface. On a cellular level, it behaves as a metabolic disruptor, potentially interfering with mitochondrial respiration and inducing lipid peroxidation within the cell membrane.


Research

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Approximately 55% of eczema patients tested exhibited sensitization when exposed to a 2% aqueous solution.
  2. 02 High-concentration suspensions (20%) did not induce visible acute erythema in specific animal models, though chronic safety remains a concern.

Transparency

Not commonly dusted
Min. effective
0.001%
Red flag below
0.001%

This ingredient is not used for skin benefits; its presence at any level in skincare is a red flag due to global regulatory bans and its status as a prohibited colorant.


The Formula

Solubility
Water
Optimal pH 3.5 – 9
0 7 14

Stability

Stable within a pH range of 3.5 to 9.0; however, it undergoes structural decomposition and loses color in strongly alkaline environments (pH > 9.0).

Conflicts

  • Anionic surfactants
  • Strong oxidizing agents
  • Alkaline environments (pH > 9)

Safety

CIR Status
Not reviewed
Max tested
0%
Pregnancy
Caution
Sensitization risk High

Prohibited for cosmetic use in the EU, Canada, and ASEAN. It is flagged as toxic if ingested, a serious eye irritant, and carries warnings regarding potential fetal damage (H361d).


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Avoid

A prohibited cosmetic colorant with documented sensitization risks and potential cellular toxicity that has no place in precision skincare.


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