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Moumoujus

BARLEY SH-OLIGOPEPTIDE-2.

Valuable / HAIR CONDITIONING, SKIN CONDITIONING

A plant-based, bio-identical growth factor that mimics human Insulin-like Growth Factor-1 (IGF-1) to signal cellular repair and renewal. Produced through precision barley biotechnology, this peptide serves as a potent architect for the skin's structural framework, specifically targeting loss of density and elasticity.

Summary

Cell-communicating ingredient Skin conditioning Skin protecting Dermal restructuring

Science

Mechanism of Action

This peptide acts as a biomimetic messenger that binds to IGF-1 receptors on fibroblasts and keratinocytes. This docking activates the PI3K/Akt signaling pathway, which triggers the biological synthesis of essential extracellular matrix proteins, including Type I collagen, elastin, and hyaluronic acid, while accelerating cell migration and wound healing.

Research

Clinical Evidence

High confidence
Effective range 1–10%
Optimal

0.0001%

Key findings

  1. 01 A 30-day clinical evaluation using Cutometer metrics (R0 and R9) confirmed a statistically significant reduction in skin sagging and a measurable increase in dermal firmness following twice-daily application.
  2. 02 In vitro NIH-referenced testing demonstrated that at concentrations up to 10 ppm, the peptide significantly promotes keratinocyte proliferation and exhibits a powerful synergy with EGF for tissue regeneration.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
1%
Red flag below
0.00001%

Because this ingredient is active at parts-per-million (ppm) levels, brands frequently include it at 'label-only' concentrations that fall below the 1 ppm (0.0001% active) clinical threshold required to trigger the PI3K/Akt signaling pathway.

The Formula

Formulation

Solubility
Water
Optimal pH 3.5 – 6.5
0 7 14

Stability

Highly thermolabile; it must be processed during the cooling phase at temperatures strictly below 40°C. It is susceptible to degradation by proteolytic enzymes and strong oxidizing agents.

Synergies

  • SH-Oligopeptide-1 (EGF)
  • Hyaluronic Acid
  • Stabilized Aqueous Systems

Conflicts

  • Proteolytic enzymes
  • Strong oxidizing agents
  • Extremes in pH (<3.0 or >8.0)
  • High thermal processing (>40°C)

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
10%
Sensitization risk Low

While formal CIR review is pending, it is categorized as safe in the EU CosIng database and demonstrates no cellular toxicity in fibroblast cultures at therapeutic levels.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

A high-precision signaling peptide essential for addressing structural skin aging, provided it is formulated at a minimum 1 ppm concentration and protected from heat.

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