Science
Mechanism of Action
The fermentation process facilitates a molecular conversion of isoquercitrin into quercetin, increasing its concentration by nearly 80-fold (from 1.4 mg/g to 114 mg/g). It suppresses melanogenesis by inhibiting Tyrosinase and Tyrosinase-Related Protein 2 (TRP-2) while simultaneously activating ERK and AKT signaling pathways to regulate cellular pigment production and provide anti-inflammatory protection.
Research
Clinical Evidence
High confidence0.025%
Key findings
- 01 In-vitro analysis confirms a significant reduction in melanin synthesis via TRP-2 inhibition at concentrations as low as 0.006%.
- 02 A clinical safety trial with 31 human participants reported 0.0% adverse reactions, validating its status as a non-irritating bioactive.
Transparency
Dusting Analysis
Because this ingredient is effective at extremely low micro-concentrations (under 0.01%), many brands list it on the label for marketing purposes ('dusting') without reaching the bioactive threshold required for pigment inhibition.
The Formula
Formulation
Stability
Highly stable in aqueous systems; fermentation naturally enhances the chemical stability of the constituent quercetin against oxidative degradation.
Synergies
- Niacinamide
- Vitamin C derivatives
- Hyaluronic Acid
Conflicts
- Strong oxidizing agents
- Highly alkaline formulations (pH > 8.0)
Safety
Safety Profile
While specifically unreviewed by the CIR, related Bacillus and Lactobacillus ferments are established as safe for cosmetic use up to 5%.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A high-performance biotech ingredient that offers precise pigment control and barrier soothing with an exceptional safety profile.
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