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AZELAOYL DIPEPTIDE-27.

Valuable / SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT, SKIN PROTECTING

A high-performance peptide derivative that chemically fuses azelaic acid with the Proline-Serine dipeptide. This precision-engineered molecule delivers the multi-corrective benefits of traditional azelaic acid—addressing hyperpigmentation and blemish-prone texture—with significantly enhanced skin penetration and a reduced risk of irritation.

Skin conditioning Brightening Sebum regulation Anti-inflammatory Skin protecting

Science

This conjugate functions as a biological multi-tasker; it inhibits tyrosinase activity to disrupt melanin synthesis for skin brightening, while simultaneously suppressing 5-alpha-reductase to normalize sebum production. Furthermore, it modulates inflammatory cytokines to calm reactive skin and provides antimicrobial support against acne-contributing bacteria.


Research

Medium confidence
Effective range 0.5–2%
Optimal

1%

Key findings

  1. 01 In vitro and in vivo testing demonstrates significant inhibition of melanin synthesis and sebum regulation comparable to parent acids but at lower concentrations due to superior peptide-driven delivery.

Transparency

Commonly dusted
Min. effective
0.5%
Red flag below
0.1%

Because it is a specialized peptide, brands often list it at 'label-claim' levels (below 0.1%) to leverage the azelaic acid name. At Moumoujus, we look for concentrations between 0.5% and 2% to ensure biological activity.


The Formula

Solubility
Water
Optimal pH 4.5 – 6.5
0 7 14

Stability

Highly stable in aqueous solutions within the slightly acidic physiological range. It is sensitive to extreme thermal conditions and should not be exposed to strong oxidizing environments.

Synergies

  • Niacinamide
  • Hyaluronic Acid
  • Vitamin C

Conflicts

  • Proteolytic enzymes
  • Strong oxidizers
  • Extreme pH environments below 3.0 or above 8.0

Safety

CIR Status
Not reviewed
Pregnancy
Safe
Sensitization risk Low

Generally regarded as safe and well-tolerated for daily topical use; offers a gentler alternative for those who cannot tolerate traditional high-percentage azelaic acid.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

An innovative, low-irritation alternative to azelaic acid that excels in brightening and sebum control for sensitive skin types.


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