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Moumoujus

AZADIRACHTA INDICA SEED EXTRACT.

Avoid CAS 84696-25-3 / SKIN CONDITIONING

Commonly known as Neem, this potent botanical extract is prized for its multifaceted approach to skin purification and structural support. It leverages a high concentration of bioactive limonoids to clarify the complexion while simultaneously defending against environmental oxidative stress.

Summary

Skin conditioning Antimicrobial Antioxidant Anti-inflammatory

Science

Mechanism of Action

The extract utilizes active constituents like azadirachtin and nimbolide to disrupt microbial cell wall integrity, effectively inhibiting unwanted bacterial and fungal growth. On a structural level, it stimulates procollagen and elastin synthesis to enhance skin density, while its flavonoid content neutralizes free radicals and suppresses pro-inflammatory cytokines to mitigate redness and irritation.

Research

Clinical Evidence

Medium confidence
Effective range 5–10%
Optimal

10%

Key findings

  1. 01 Demonstrated peak free radical scavenging activity of 66.34% at a concentration of 200.0 μg/mL in ethanolic extracts.
  2. 02 Identified 10.0% as the optimal concentration for inhibiting specific fungal species growth.
  3. 03 Industry standards establish a 5.0-10.0% range for achieving therapeutic soothing and anti-acne benefits.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
5%
Red flag below
1%

While often included for marketing 'Neem' benefits, the clinical threshold for antimicrobial and anti-inflammatory efficacy starts at 5%. Inclusion rates below 1% are unlikely to provide the corrective benefits associated with its bioactive limonoids.

The Formula

Formulation

Solubility
Both
Optimal pH 4 – 7
0 7 14

Stability

Maintains peak stability in mildly acidic environments (pH 4.0-6.0). It is susceptible to hydrolytic decomposition in high-water formulas if not properly stabilized.

Synergies

  • Antioxidants
  • Moisturizing agents
  • Anti-acne actives

Conflicts

  • Strongly alkaline solutions
  • Strongly acidic solutions
  • Unstabilized aqueous systems

Safety

Safety Profile

CIR Status
Insufficient data
Max tested
0%
Pregnancy
Caution
Sensitization risk Moderate

Classified as a CMR substance (Carcinogenic, Mutagenic, or Toxic to Reproduction) in the EU, leading to a total prohibition under Regulation 2023/1490. Use is strictly regulated or prohibited in several regions; formulate with extreme caution outside these jurisdictions.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Avoid

While biologically potent for acne and aging, its recent EU-wide prohibition due to reproductive toxicity concerns makes it a high-risk ingredient for precision skincare.

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