Science
Mechanism of Action
Atelocollagen provides a dual-action approach to skin health: it functions as a high-performance moisture reservoir by forming a protective film that significantly reduces transepidermal water loss (TEWL). At a biological level, it serves as a glycine donor, utilizing the GlyT1 transporter pathway to elevate intracellular glycine levels and stimulate endogenous collagen synthesis in aging dermal cells.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 Topical application over 60 days demonstrated statistically significant reductions in periorbital wrinkle depth and enhanced skin elasticity.
- 02 At a concentration of 150 µg/mL, it successfully upregulates GlyT1 transporters to promote fresh collagen production in aged skin models.
Transparency
Dusting Analysis
While CIR data reflects historical leave-on concentrations as low as 0.005%, efficacy in collagen synthesis and visible wrinkle reduction typically requires higher inclusion levels found in raw material blends (1-5%). Formulas listing it near the bottom of the INCI may only be utilizing its basic humectant properties rather than its regenerative potential.
The Formula
Formulation
Stability
Highly thermolabile; it must be incorporated during the cool-down phase as it denatures above 30-40°C. It may undergo gelation (fibrillogenesis) if the formulation pH reaches physiological levels (~7.4).
Synergies
- Adenosine
- Hyaluronic Acid
- Peptides
Conflicts
- Proteolytic enzymes
- Temperatures >40°C
- Strongly alkaline environments
- Prolonged UV exposure
Safety
Safety Profile
The 0.005% max concentration reported by CIR (2017) reflects industry surveys of leave-on products, not a safety ceiling; higher concentrations are considered safe due to its high biocompatibility.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An elite humectant and structural protein that offers superior biocompatibility and measurable anti-wrinkle benefits when formulated under strict temperature and pH controls.
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References
Sources