Science
Mechanism of Action
Aspergillus-derived enzymes catalyze the breakdown of complex proteins and starches into bio-available amino acids, peptides, and organic acids like ferulic and kojic acid. These metabolites function as Natural Moisturizing Factors (NMFs) and biochemical signals that upregulate the expression of Filaggrin (FLG) for barrier strength, Aquaporin 3 (AQP3) for water transport, and Hyaluronan Synthase 1 (HAS1) for internal hydration.
Research
Clinical Evidence
High confidence1.25%
Key findings
- 01 In vitro analysis of red rice fermented by Aspergillus (RRFA) at 1.25% demonstrated significant upregulation of AQP3, Filaggrin, and Hyaluronan Synthase 1, directly improving cellular hydration and barrier integrity.
- 02 An 8-week clinical trial utilizing a 0.25% concentration in tandem with sialic acid showed a measurable reduction in periorbital wrinkles and enhanced Type I collagen synthesis in dermal fibroblasts.
Transparency
Dusting Analysis
While this ingredient is effective at concentrations as low as 0.25% for collagen support, barrier repair benefits are most prominent at 1.25%. Formulations using it below 0.25% likely include it for marketing claims rather than physiological impact.
The Formula
Formulation
Stability
Highly stable in aqueous solutions; however, the bioactive metabolites are prone to photodegradation and require UV-protective or opaque packaging.
Synergies
- Sialic Acid
- Hyaluronic Acid
- Niacinamide
Conflicts
- Strong oxidizing agents
- Alkaline environments (pH > 8.0)
- High concentrations of anionic surfactants
Safety
Safety Profile
The ingredient is a tri-blend of components (ferments, rice, and keratin) that are individually recognized as safe and non-irritating.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A sophisticated multi-functional active that bridges the gap between hydration and anti-aging by stimulating the skin's internal water-management systems.
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