Science
Mechanism of Action
Through fermentation, large rice proteins and starches are enzymatically cleaved into low-molecular-weight peptides, amino acids, and ferulic acid. These bioavailable compounds upregulate the mRNA expression of Hyaluronan Synthase 1 (HAS1) and Aquaporin-3 (AQP3), facilitating superior water transport and synthesis. Additionally, it provides photoprotection by scavenging ROS and inhibits tyrosinase to manage melanin-induced hyperpigmentation.
Research
Clinical Evidence
High confidence1.25%
Key findings
- 01 In vitro research in 2024 demonstrated that a 1.25% concentration significantly boosted mRNA levels of HAS1 and skin water content, with no additional efficacy gains observed at 3%.
- 02 2024 NIH/PMC study confirmed that while a 3.0% concentration supports barrier preservation, the primary hydration benefits are fully realized at lower thresholds (1.25%).
Transparency
Dusting Analysis
Because clinical efficacy for moisture content peaks at 1.25%, formulations using less than 1% are likely 'dusting' for marketing claims without providing significant biological upregulation of water channels.
The Formula
Formulation
Stability
Aqueous extract remains stable at room temperature but is susceptible to the degradation of its phenolic compounds if exposed to UV radiation or temperatures exceeding standard ambient conditions.
Synergies
- Niacinamide
- Hyaluronic Acid
- Vitamin C
Conflicts
- strong oxidizers
- highly acidic environments (pH <3.5)
- highly alkaline environments (pH >8.5)
Safety
Safety Profile
Aspergillus oryzae is classified as Generally Recognized as Safe (GRAS) for food consumption, which correlates to its excellent safety profile in topical skincare.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A potent, scientifically validated ferment that delivers peak hydration and antioxidant benefits at a precise 1.25% concentration.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources