Science
Mechanism of Action
This ingredient functions by acting as an antagonist of Lyn kinase, thereby attenuating substance P/MRGPRX2-mediated chronic urticaria and mast cell activation, which underpins its anti-inflammatory effects. Additionally, artemisinic acid demonstrates inhibitory actions on melanogenesis, leading to reduced melanin content and suppressed cellular proliferation relevant to pigmentary issues.
Research
Clinical Evidence
Low confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Artemisinic acid is soluble in ethanol at a concentration of 16 mg/ml. As a monocarboxylic acid, its solubility and stability are anticipated to be pH-dependent. Related derivatives demonstrate stability within a pH range of 2 to 6, with degradation potentially accelerated outside of this window.
Safety
Safety Profile
There are no specific safety assessments from major cosmetic regulatory bodies such as CIR, SCCS, or FDA for Artemisinic Acid as a cosmetic ingredient. However, Artemisia Annua extract, a related botanical, is listed in China's 'Catalogue of Used Cosmetic Ingredients,' and artemisinin was previously certified by the former American CTFA.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While exhibiting promising preclinical mechanisms for inflammation and hyperpigmentation, Artemisinic Acid currently lacks comprehensive human clinical studies and formal regulatory safety assessments as a cosmetic ingredient, warranting further research.
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References
Sources