Science
Mechanism of Action
It functions by inhibiting the production of pro-inflammatory cytokines, specifically TNF-α and IL-6, through the modulation of the NF-κB signaling pathway. Additionally, its flavonoid content—notably capillarisin—functions as a potent scavenger of reactive oxygen species (ROS) and exhibits secondary tyrosinase inhibition to mitigate post-inflammatory hyperpigmentation.
Research
Clinical Evidence
Medium confidence2%
Key findings
- 01 In vitro evaluation of anti-inflammatory effects on human keratinocytes
- 02 Analysis of capillarisin-mediated inhibition of melanogenesis
- 03 Assessment of antioxidant capacity via DPPH radical scavenging assays
Transparency
Dusting Analysis
Due to its trending status in 'Cica' and 'Calming' marketing, it is frequently included at concentrations below 0.1% to claim botanical benefits without achieving the threshold required for cytokine suppression.
The Formula
Formulation
Stability
Heat sensitive; should be incorporated during the cooling phase of formulation (below 40°C) to preserve phenolic integrity.
Synergies
- Centella Asiatica Extract
- Niacinamide
- Dipotassium Glycyrrhizate
Conflicts
- Strong oxidizing agents
Safety
Safety Profile
Generally regarded as non-toxic and non-irritating; traditional use suggests high dermatological tolerance.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A highly effective botanical intervention for inflammatory-driven skin concerns when formulated at a minimum 1% concentration.
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