Science
Mechanism of Action
The extract operates via a tripartite physiological approach: it inhibits the proliferation of P. acnes and S. epidermidis through direct antimicrobial action, suppresses the NF-kB inflammatory signaling pathway in keratinocytes, and exerts a sebosuppressive effect by downregulating lipogenesis within the sebocytes.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 A 4-week clinical study (Park, H. et al.) confirmed that a 2% concentration significantly reduced total sebum output and diminished both open and closed comedones. Research also established a Minimal Inhibitory Concentration (MIC) of 2.25 mg/ml against P. acnes.
Transparency
Dusting Analysis
Due to its complex botanical INCI, this ingredient is frequently used at 'claim levels' (below 0.5%) for marketing purposes. To achieve the sebosuppressive and anti-comedogenic benefits observed in clinical trials, a concentration of at least 2% is required.
The Formula
Formulation
Stability
Highly stable in aqueous solutions and emulsions; however, it is sensitive to photo-oxidation and thermal degradation. Formulations should be housed in UV-protective packaging and stored in cool environments to maintain flavonoid integrity.
Synergies
- Niacinamide (enhanced sebum control)
- Salicylic Acid (pore clearance and antimicrobial synergy)
- Hyaluronic Acid (balancing oil-control with hydration)
Conflicts
- Strong oxidizing agents
- Formulations with pH levels below 3.0 or above 8.0
Safety
Safety Profile
ECOCERT and COSMOS approved. The individual botanical components have a long history of safe use in traditional medicine and food, with no known systemic toxicity in topical applications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A sophisticated botanical alternative to traditional acne treatments that successfully bridges the gap between natural sourcing and clinical oil-control efficacy.
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References
Sources