Science
Mechanism of Action
Arachidic acid integrates directly into the stratum corneum's lamellar structure, acting as an emollient and occlusive shield. It functions in synergy with ceramides and cholesterol to repair the intercellular lipid matrix, effectively sealing in hydration and providing a physical defense against environmental stressors.
Research
Clinical Evidence
High confidence1%
Key findings
- 01 Vital for restoring the lamellar structure of the stratum corneum when utilized in a physiological 3:1:1 ratio alongside ceramides and cholesterol.
- 02 Demonstrated high biocompatibility in 3D skin models with zero observed phototoxicity or irritation, confirming its suitability for reactive skin.
Transparency
Dusting Analysis
While safe at very low levels (0.065%), clinical barrier repair benefits are most prominent at concentrations above 0.1%. Formulas listing it at the very bottom of the deck may only be using it for emulsification rather than active barrier restoration.
The Formula
Formulation
Stability
Requires heating to approximately 75°C during the oil phase. It is highly stable against oxidation compared to unsaturated fatty acids, though airtight packaging is preferred.
Synergies
- Ceramides
- Cholesterol
- Phytosphingosine
Conflicts
- Strong bases
- Cationic surfactants
- Strong oxidizing agents
Safety
Safety Profile
The 0.065% max concentration refers to current reported usage in facial preparations, though the CIR notes higher concentrations are safe based on data from similar fatty acids.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An essential skin-native lipid for barrier reconstruction, particularly effective when formulated in precise ratios with ceramides and cholesterol.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources