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Moumoujus

APIUM GRAVEOLENS EXTRACT.

Valuable CAS 89997-34-2 / SKIN CONDITIONING

Derived from celery seeds and stems, this botanical powerhouse offers a multifaceted approach to skin health, combining potent antioxidant protection with advanced sebum-regulating capabilities. It is particularly valued in high-performance skincare for its ability to reinforce the skin barrier and promote cellular recovery through its rich concentration of alkyl-phthalides and flavonoids.

Summary

Skin conditioning Antioxidant Sebum regulation Barrier reinforcement

Science

Mechanism of Action

Apium Graveolens Extract functions through three primary pathways: it utilizes flavonoids like apigenin and luteolin to neutralize reactive oxygen species (ROS), employs alkyl-phthalides to modulate lipid production and collagen synthesis, and accelerates tissue repair by upregulating Cytokeratin-17 (CK-17) expression and fibroblast activity.

Research

Clinical Evidence

High confidence
Effective range 0.2–5%
Optimal

1%

Key findings

  1. 01 Significantly enhanced re-epithelialization and fibroblast proliferation in compromised skin, reducing wound area and microbial colonization.
  2. 02 Specific phthalides demonstrated the ability to stimulate dermal collagen production while balancing scalp sebum levels.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.2%
Red flag below
0.05%

While beneficial at levels as low as 0.2% for wound healing, many mass-market formulations include it at 'label-claim' levels (below 0.05%) where its antioxidant and sebum-regulating properties are physiologically negligible.

The Formula

Formulation

Solubility
Both
Optimal pH 4.5 – 7
0 7 14

Stability

Contains volatile terpenes and phthalides sensitive to photo-oxidation. Stability is maximized when encapsulated in liposomes or nanocrystals to protect apigenin content.

Synergies

  • Liposomal delivery systems
  • Niacinamide for pore refinement
  • Ceramides for barrier support

Conflicts

  • High UV exposure (without UV filters)
  • Strong oxidizing agents
  • Prolonged atmospheric oxygen exposure

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
5%
Pregnancy
Safe
Sensitization risk Low

Recognized as GRAS by the FDA. Note that oxidation of its limonene components over time can increase sensitization potential, requiring airtight packaging.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

An expertly balanced botanical that excels in sebum control and structural skin support when formulated to prevent oxidation.

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