Science
Mechanism of Action
The extract utilizes a high density of C-glucosylxanthones (mangiferin) and tormentic acids to inhibit the release of Calcitonin Gene-Related Peptide (CGRP) from sensory neurons, thereby reducing neurogenic inflammation. Concurrently, it acts as a molecular shield by scavenging reactive oxygen species (ROS) and absorbing UV radiation, while stimulating cellular regeneration to fortify the physical skin barrier.
Research
Clinical Evidence
High confidence3%
Key findings
- 01 In a human innervated epidermis model (RHE-huSN), a 3.0% concentration achieved a 30% reduction in CGRP neuropeptide release, confirming significant neuro-soothing activity.
- 02 At 0.11%, the extract demonstrates antioxidant scavenging capacity comparable to synthetic Trolox, providing effective photoprotection against oxidative stress.
Transparency
Dusting Analysis
While it provides basic antioxidant support at levels as low as 0.11%, many commercial formulations 'dust' this ingredient at negligible concentrations for marketing. To achieve its clinically validated neuro-soothing and anti-inflammatory benefits, a concentration closer to 3.0% is required.
The Formula
Formulation
Stability
Maintains peak stability in slightly acidic to neutral environments; requires storage away from high heat. Phenolic degradation occurs in alkaline conditions.
Synergies
- Glycerin
- Butylene Glycol
- Soothe-centric peptides
Conflicts
- Strong oxidizing agents
- High alkaline formulations (pH > 8.0)
Safety
Safety Profile
Verified as non-sensitizing in h-CLAT and Sens-Is in vitro models. Widely utilized in sensitive skin dermatology without reported adverse effects.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An exceptional bioactive botanical for sensitive and reactive skin types, provided it is formulated at concentrations sufficient to trigger its neuro-soothing pathways.
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