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Moumoujus

ANREDERA CORDIFOLIA LEAF EXTRACT.

Valuable / HUMECTANT, SKIN CONDITIONING

Commonly known as Binahong, this potent botanical extract is a powerhouse for tissue regeneration and dermal repair. It is particularly valued in precision skincare for its ability to accelerate wound healing and suppress inflammatory responses in compromised skin barriers.

Summary

Skin Regenerating Anti-inflammatory Antimicrobial Antioxidant Humectant

Science

Mechanism of Action

The extract functions by stimulating fibroblast proliferation and upregulating the production of Type I collagen and Vascular Endothelial Growth Factor (VEGF), essential components for structural integrity and angiogenesis. It further protects the skin matrix by inhibiting Matrix Metalloproteinases (MMP1 and MMP12) and exhibits targeted antimicrobial activity against P. acnes and S. aureus by disrupting their cellular membranes.

Research

Clinical Evidence

High confidence
Effective range 0.005–10%
Optimal

5%

Key findings

  1. 01 Demonstrated superior wound contraction and accelerated healing in both normal and hyperglycemic models at a 10% concentration.
  2. 02 A 5% topical application proved effective in treating thermal burns by modulating inflammation and promoting rapid tissue re-epithelialization.
  3. 03 In vitro data shows that even at a minimal 0.005% concentration, the extract significantly reduces inflammatory markers like Nitric Oxide and IL-6.

Transparency

Dusting Analysis

Commonly dusted
Min. effective
0.1%
Red flag below
1%

While potent anti-inflammatory benefits are observed at trace levels (0.005%), structural tissue repair and significant clinical healing typically require concentrations between 3% and 10%. Products listing this ingredient at the very end of the INCI deck are likely utilizing it for marketing claims rather than functional regeneration.

The Formula

Formulation

Solubility
Both
Optimal pH 5 – 7.5
0 7 14

Stability

The active flavonoid Vitexin has limited water solubility; stability is maximized using nanoparticle delivery systems or ethanol-based extraction. It remains stable in common gel matrices through temperature fluctuations.

Synergies

  • Antioxidants
  • Hyaluronic Acid
  • Peptides

Conflicts

  • Strong oxidizing agents
  • Formulations with pH below 3.0

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
35%
Pregnancy
Safe
Sensitization risk Low

Extensive history of use in traditional medicine and as an edible plant; animal and in vitro studies show no acute toxicity or cytotoxicity to human fibroblasts.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

A highly effective botanical for barrier repair and inflammatory control, provided it is formulated at clinically relevant concentrations.

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