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ANNONA SQUAMOSA FLOWER EXTRACT.

Valuable / SKIN CONDITIONING

A sophisticated botanical extract derived from the flowers of the Sugar Apple tree, rich in a diverse array of 20 bioactive phytochemicals. It serves as a multifunctional skin-conditioning agent that balances cellular health with potent antioxidant protection.

Skin conditioning Antioxidant Anti-inflammatory Cellular protection

Science

The extract operates through a synergistic blend of flavonoids and phenolic compounds that neutralize free radicals, combined with sesquiterpenes like Germacrene D which modulate inflammatory pathways. Recent molecular data also suggests it supports cellular homeostasis by inhibiting abnormal cell migration and promoting healthy cell turnover cycles.


Research

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 GC-MS profiling (2025) confirmed 20 bioactives including Germacrene D and γ-Elemene with antioxidant and anti-inflammatory properties.
  2. 02 Ethanolic flower extract demonstrated dose-dependent pro-apoptotic and anti-migratory activity in scratch wound assays on cervical cancer cell lines.

Transparency

Commonly dusted
Min. effective
0.5%
Red flag below
0.1%

Due to its botanical nature and the lack of a standardized minimum effective dose for topical skincare, this ingredient is frequently included in concentrations below 0.1% for marketing purposes rather than therapeutic efficacy.


The Formula

Solubility
Both
Optimal pH 4 – 7
0 7 14

Stability

Contains volatile aromatic compounds and sesquiterpenes that are sensitive to thermal degradation; cold-process manufacturing or late-stage addition below 40°C is recommended.

Synergies

  • Vitamin E
  • Ferulic Acid
  • Squalane

Conflicts

  • Strong oxidizing agents
  • High-heat processing

Safety

CIR Status
Not reviewed
Pregnancy
Safe
Sensitization risk Low

Listed in the EU CosIng as a safe skin-conditioning agent without specific regulatory restrictions under Regulation (EC) No 1223/2009.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A high-potential botanical antioxidant with a unique sesquiterpene profile that provides excellent conditioning and protective benefits for all skin types.


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References