Science
Mechanism of Action
Functions as a selective CB2 receptor agonist within the skin's endocannabinoid system, effectively downregulating the TRPV1 inflammatory pathway and suppressing IL-31RA itch receptors. It further modulates skin comfort by inhibiting local cortisol production and providing potent antioxidant defense via high concentrations of catechins and epicatechins.
Research
Clinical Evidence
High confidence3%
Key findings
- 01 Clinical evaluation of 117 volunteers demonstrated that a 3.0% concentration reduced skin itching by 73% and overall sensitivity by up to 60%.
- 02 Technical testing of 10.0% peel extract showed an inherent SPF greater than 6 along with significant antimicrobial activity against P. aeruginosa.
Transparency
Dusting Analysis
While this extract provides antioxidant value at lower levels, its primary neurocosmetic function—reducing itch and sensitivity—requires a clinical threshold of 3.0%. Formulas claiming 'soothing' or 'stress-relief' benefits using less than 1.0% are likely leveraging the ingredient for marketing rather than biological efficacy.
The Formula
Formulation
Stability
Heat-sensitive; must be incorporated during the cooling phase at temperatures below 40°C. High electrolyte concentrations may destabilize certain standardized versions.
Synergies
- Ceramides
- Panthenol
- Centella Asiatica
- Niacinamide
Conflicts
- Strong oxidizing agents
- Highly acidic formulations (pH < 5.0)
- High electrolyte loads
Safety
Safety Profile
While not yet specifically reviewed by the CIR, its closely related botanical parent (A. cherimola) is established as a safe skin-conditioning agent with no evidence of genotoxicity.
Your Skin
Skin Compatibility
Our Assessment
Verdict
An exceptional choice for precision skincare targeting the endocannabinoid system to provide measurable relief for reactive and stressed skin types.
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References
Sources