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Anhydroglucitol.

Valuable CAS 154-58-5 / ANTIPLAQUE, HUMECTANT, SKIN CONDITIONING

Anhydroglucitol is a high-performance sugar-derived humectant that optimizes the skin's internal hydration network. It acts as a structural analog to glucose, providing both immediate surface moisture and long-term barrier reinforcement for a resilient complexion.

Humectant Barrier Repair Skin Conditioning Surfactant Buffer

Science

It functions as a moisture-binding monosaccharide that enhances the Skin's Natural Moisturizing Factor (NMF). By regulating 'hydric flow' within the epidermis, it stimulates the synthesis of essential lipids and proteins required for healthy keratinocyte differentiation and barrier integrity.


Research

High confidence
Effective range 0.5–5%
Optimal

1.5%

Key findings

  1. 01 Low-dose 0.5% applications in cleansers significantly mitigate surfactant harshness while providing sustained hydration.
  2. 02 Concentrations between 1% and 5% in leave-on formulas demonstrate measurable moisture retention lasting up to 72 hours.

Transparency

Commonly dusted
Min. effective
0.5%
Red flag below
0.1%

Because it is active at levels as low as 0.5% in rinse-off products, brands often include it at negligible amounts (below 0.1%) to claim 'long-term hydration' without providing the concentration necessary to actually counter surfactant irritation or reach the 72-hour efficacy window.


The Formula

Solubility
Water
Optimal pH 6 – 11
0 7 14

Stability

A highly stable pyranose ring structure that resists thermal and chemical degradation. It is exceptionally water-soluble (approx. 674 g/L).

Synergies

  • Xylitol
  • Xylitylglucoside
  • Glycerin

Safety

CIR Status
Safe as used
Max tested
4.6%
Pregnancy
Safe
Sensitization risk Low

Generally regarded as safe; while specific 2018 surveys noted 0.17% in bubble baths, its chemical group is safely used up to 2.8% in leave-on skincare.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A sophisticated humectant that goes beyond simple moisture by biologically supporting the skin's barrier and lipid synthesis.


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