Science
Mechanism of Action
Rich in chalcones and flavonoids, it neutralizes free radicals and inhibits tyrosinase activity to reduce melanin. It also suppresses pro-inflammatory cytokines, promoting cell recovery and barrier hydration.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Demonstrated efficacy at 8% in inhibiting melanin increase, comparable to 4% hydroquinone in animal models.
- 02 Shown to potently inhibit nitric oxide and pro-inflammatory cytokines (IL-1B, IL-6) in cellular studies.
- 03 Commonly used in 0.1%-1.0% in serum gels for antioxidant activity and tyrosinase inhibition.
Transparency
Dusting Analysis
No specific data suggests this ingredient is commonly used at sub-efficacious 'dusting' levels in cosmetic formulations.
The Formula
Formulation
Stability
Active chalcones are sensitive to light and oxidation, often requiring antioxidants or amber packaging. Extracts can be made water-dispersible.
Conflicts
- Strong oxidizing agents
- Extreme pH conditions (>8 or <4) which may degrade bioactive chalcones
Safety
Safety Profile
CIR has not formally reviewed it for cosmetic limits, but its EU 'Novel Food' approval indicates a high systemic safety profile. No significant topical irritancy or toxicity is reported.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Angelica Keiskei Leaf/Stem Extract is a valuable multi-functional ingredient offering significant antioxidant, anti-inflammatory, and brightening benefits with good skin compatibility.
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