Science
Mechanism of Action
This extract functions as an antioxidant and anti-inflammatory agent, primarily through coumarins and polyacetylenes. It inhibits nitric oxide and TNF-α production, while ferulic acid and kaempferol scavenge ROS and inhibit tyrosinase for photoprotective and brightening effects.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In vitro studies show significant inhibition of NO production (IC50: 4.4-4.8 μM for falcarindiol/falcarinol) in macrophages, indicating strong anti-inflammatory potential.
- 02 Studies on melanin production in B16 melanoma cells indicated a decrease in melanogenesis, suggesting potential for skin-brightening.
Transparency
Dusting Analysis
There is no specific data available regarding common dusting practices for this extract in cosmetic formulations.
The Formula
Formulation
Stability
Extracts contain heat-sensitive compounds; supercritical CO2 extraction is preferred. It is stable within typical skin-neutral pH ranges.
Conflicts
- Strong oxidizing agents
- High heat (>80°C during formulation)
Safety
Safety Profile
While not CIR reviewed, it's listed in EU CosIng. Furanocoumarins in Angelica can be photosensitizing, though specific levels in leaf/stem are less documented than root extracts.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This multi-functional botanical ingredient offers significant antioxidant, anti-inflammatory, and brightening benefits, making it a valuable addition to various skincare formulations.
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References
Sources