Science
Mechanism of Action
This extract inhibits collagen-degrading enzymes (MMPs) while stimulating Type I collagen synthesis. It also brightens skin by promoting melanosome degradation and offers antioxidant protection by scavenging reactive oxygen species.
Research
Clinical Evidence
High confidence2%
Key findings
- 01 Topical application of 2% Japanese Angelica Root Extract significantly improved hyperpigmentation and age spots by promoting cathepsin activity for melanosome degradation.
- 02 In vitro, 0.01% Angelica acutiloba extract increased type I collagen synthesis by 55.5% and inhibited MMP-2 activity by 36.6% in human dermal fibroblasts.
Transparency
Dusting Analysis
No data available suggests this ingredient is commonly dusted.
The Formula
Formulation
Stability
Optimal stability occurs in neutral to near-neutral pH (5.0-7.5), with compromised stability in highly acidic conditions. Its solubility varies; oil extracts are oil-soluble, while botanical extracts in glycol/water bases are water-soluble.
Conflicts
- Strong acids
- Strong oxidizing agents
Safety
Safety Profile
While not yet reviewed by CIR, this extract is listed in EU CosIng and JSQI as a safe skin-conditioning agent. Oral toxicity studies indicate a high NOAEL of >2000 mg/kg/day in rats.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Angelica acutiloba leaf extract is a valuable multi-functional ingredient, effectively addressing anti-aging, brightening, and skin conditioning with a favorable safety profile and low irritancy.
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References
Sources