Science
Mechanism of Action
This extract inhibits tyrosinase and MITF to reduce melanin production, suppresses MMP-1 to prevent collagen degradation, and stimulates adipocyte differentiation for a 'lipofilling' effect, increasing skin volume and plumpness.
Research
Clinical Evidence
Medium confidence2%
Key findings
- 01 Clinical trials with 2% Anemarrhena Asphodeloides extract confirmed skin-whitening and significant anti-aging effects by inhibiting MMP-1 and melanin biosynthesis.
- 02 In-vitro studies demonstrated potent anti-wrinkle activity by inhibiting MMP-1 protein expression at concentrations as low as 0.31 µg/mL.
Transparency
Dusting Analysis
No specific data indicates this ingredient is commonly dusted in formulations.
The Formula
Formulation
Stability
Typically supplied in a glycol base, the callus conditioned media is stable in standard oil-in-water emulsions, with optimal performance between pH 5.0 and 7.0.
Conflicts
- High concentrations of Vitamin C (L-Ascorbic Acid)
- Strong oxidizing agents
- Low pH exfoliating acids (<3.5)
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) has not specifically reviewed this callus conditioned media, though the root extract is commonly used up to 5% in 'lipofilling' complexes with negligible cytotoxicity.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Anemarrhena Asphodeloides Callus Conditioned Media Extract is a valuable ingredient, effectively plumping, brightening, and reducing wrinkles with a good safety and skin compatibility profile.
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References
Sources