Science
Mechanism of Action
This exo-acting carbohydrase hydrolyzes alpha-1,4 and alpha-1,6 glycosidic linkages, releasing glucose. In skincare, it specifically targets and degrades existing AGEs, preventing protein cross-linking and maintaining skin's structural integrity.
Research
Clinical Evidence
Medium confidence1%
Key findings
- 01 MDPI: The Establishment and Application of a Method for the Systematic Evaluation... of Cosmetic Ingredients Based on the Inhibition and Degradation of Advanced Glycation End Products (2023)
Transparency
Dusting Analysis
No specific data on 'dusting' practices for amyloglucosidase is available. As an enzyme, its efficacy is highly dependent on proper formulation and stability, rather than merely its concentration.
The Formula
Formulation
Stability
Highly stable at acidic pH levels typical of the skin barrier (4.0-5.5). Activity significantly decreases if pH shifts more than 1.0 unit from its optimum (pH 4.0-4.5), and it loses stability above 60°C.
Conflicts
- Copper (Cu2+)
- Zinc (Zn2+)
- Mercury (Hg2+)
- SDS (Sodium Dodecyl Sulfate)
- EDTA
Safety
Safety Profile
While not formally reviewed by CIR for topical leave-on products, it is Generally Recognized as Safe (GRAS) by the FDA for food use. EWG rates it low hazard but notes potential for moderate respiratory/skin allergy sensitization as an enzyme.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Amyloglucosidase is a valuable anti-glycation enzyme with a clear mechanism for degrading AGEs, though further research on topical safety, irritancy, and optimal concentration ranges would solidify its standing.
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