Science
Mechanism of Action
It reduces inflammation by inhibiting TLR4/NF-κB and TNF-α pathways. In wound healing, it accelerates tissue regeneration by increasing IL-10 and regulating TGF-β1/VEGF, while tyrosinase inhibition leads to brighter skin. As a powder, it offers physical exfoliation.
Research
Clinical Evidence
Medium confidence20%
Key findings
- 01 20% Ampelopsis japonica extract (AJE) significantly promoted wound healing, angiogenesis, and collagen formation in scalded rats.
- 02 Topical ethanol extract notably reduced scaling, erythema, and epidermal hyperplasia in contact dermatitis mouse models.
- 03 Extracts demonstrated anti-tyrosinase and anti-melanogenic activity for hyperpigmentation treatment.
Transparency
Dusting Analysis
As a fine powder, this ingredient can be added at minimal concentrations for texture or as a filler, rather than for its primary active benefits.
The Formula
Formulation
Stability
The dry root powder is stable. Bioactive components in extracts, such as gallic acid and catechins, are most stable in slightly acidic to neutral environments.
Conflicts
- Strong oxidizing agents
- Strongly alkaline environments (may degrade phenolic antioxidants)
Safety
Safety Profile
While not formally reviewed by the CIR, it is listed in the EU CosIng database and used in traditional Chinese medicine with low reported toxicity. It is generally considered safe for topical use in botanical mixtures.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A versatile botanical ingredient with demonstrated anti-inflammatory, wound-healing, and brightening benefits, making it a valuable addition to many skincare formulations.
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