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AMMONIUM IODIDE.

Questionable CAS 12027-06-4 / ANTIMICROBIAL

A water-soluble inorganic salt that functions as an antimicrobial agent in topical skincare formulations. Historically employed in dermatological treatments for acne and fungal infections, it releases iodide ions that provide antiseptic properties. However, its formulation challenges and irritation potential limit its use in modern precision skincare.

antimicrobial

Science

Functions as an antimicrobial agent by releasing iodide ions that exhibit antiseptic effects, potentially inhibiting bacterial and fungal growth associated with acne and skin infections through ionic disruption of microbial cellular processes.


Research

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Historical dermatological applications demonstrated antimicrobial efficacy in acne and fungal infection treatments
  2. 02 Chemical stability evaluation at 0.1M concentration showed pH of approximately 4.6

Transparency

Not commonly dusted

Not commonly used in modern cosmetic formulations due to stability issues and irritation potential, making dusting practices unlikely


The Formula

Solubility
Water
Optimal pH 4.5 – 6.5
0 7 14

Stability

Highly hygroscopic and photosensitive compound that decomposes in humid conditions, developing yellow-brown discoloration from free iodine liberation. Requires stabilization with approximately 1% ammonium hypophosphite in aqueous solutions.

Synergies

  • Ammonium hypophosphite (stabilizer)

Conflicts

  • Strong oxidizing agents
  • Strong acids and bases
  • Light exposure
  • High humidity conditions

Safety

CIR Status
Not reviewed
Sensitization risk Moderate

Classified as Category 2 irritant for skin and eyes under GHS criteria. Lacks comprehensive CIR safety assessment, though related ammonium compounds have been evaluated favorably when formulated to minimize irritation.


Your Skin

Yes Normal
No Dry
Yes Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Questionable

Limited modern applications due to formulation instability and moderate irritation potential outweigh historical antimicrobial benefits.


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