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AMMONIUM GLYCOLATE.

Valuable CAS 35249-89-9 / BUFFERING, KERATOLYTIC

A water-soluble salt form of glycolic acid that delivers gentle yet effective exfoliation while providing pH buffering properties. This alpha-hydroxy acid derivative offers improved skin penetration and moisturizing benefits compared to traditional glycolic acid formulations.

Chemical exfoliant pH adjuster Skin conditioning agent Humectant

Science

Functions as a chemical exfoliant by disrupting intercellular bonds (desmosomes) between dead skin cells in the stratum corneum, accelerating natural desquamation processes. The ammonium salt structure enhances water solubility and provides humectant properties, while stimulating cellular turnover to reveal smoother, more refined skin texture.


Research

High confidence
Effective range 1–10%
Optimal

5%

Key findings

  1. 01 CIR Panel safety assessment confirmed non-sensitizing properties at concentrations up to 10% with zero comedogenic potential
  2. 02 Professional-grade formulations demonstrated safety at 30% concentration when maintained at pH 3.0 or higher

Transparency

Not commonly dusted

Well-established AHA with clear concentration guidelines and extensive safety data


The Formula

Solubility
Water
Optimal pH 3 – 4.5
0 7 14

Stability

Exhibits excellent aqueous solubility due to ionic structure. Maintains stability under standard storage conditions but requires protection from extreme pH environments and excessive heat exposure.

Synergies

  • Hyaluronic acid
  • Niacinamide
  • Ceramides

Conflicts

  • Strong acids
  • Strong bases
  • Cationic surfactants
  • Oxidizing agents

Safety

CIR Status
Safe with restrictions
Max tested
10%
Pregnancy
Safe
Sensitization risk Low

Consumer formulations limited to 10% at pH ≥3.5. Professional treatments may use up to 30% at pH ≥3.0. Mandatory sun protection advisories required due to photosensitizing effects.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

A well-researched AHA salt offering effective exfoliation with enhanced solubility and reduced irritation potential compared to free glycolic acid.


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