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AMMONIUM COCOYL ISETHIONATE.

Valuable CAS 223705-57-5 / CLEANSING, SURFACTANT - CLEANSING

Ammonium Cocoyl Isethionate (ACI) is a gentle anionic surfactant renowned for its exceptional mildness. It effectively cleanses the skin without compromising its natural barrier function.

cleansing surfactant

Science

This anionic surfactant reduces water's surface tension, enabling it to emulsify and lift dirt and oils. Its large micelle size of approximately 33.5 Å prevents penetration of the stratum corneum, preserving the skin's lipid barrier.


Research

High confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 A 2.9% concentration was found to be significantly milder than Sodium Lauryl Sulfate in clinical irritancy testing.
  2. 02 Local Lymph Node Assays (LLNA) up to 50% concentration showed no skin sensitization.

Transparency

Not commonly dusted

No specific data on dusting behavior is available for Ammonium Cocoyl Isethionate.


The Formula

Solubility
Water
Optimal pH 5 – 7.5
0 7 14

Stability

More water-soluble than SCI, it is prone to hydrolysis at extreme pH (below 5 or above 8), which can affect foaming or lead to recrystallization.

Conflicts

  • Cationic polymers (may cause precipitation at high concentrations)
  • Strongly acidic environments (causes hydrolysis)
  • Strongly alkaline environments

Safety

CIR Status
Safe as used
Max tested
53%
Sensitization risk Low

The CIR concludes it is safe when formulated to be non-irritating. Rinse-off product safety was updated to 53% based on current practices.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

Ammonium Cocoyl Isethionate is a valuable, mild cleansing agent, highly compatible with various skin types, making it ideal for gentle yet effective formulations.


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