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AMINOPROPYL TOCOPHERYL PHOSPHATE.

Valuable CAS 348099-49-0 / ANTIOXIDANT, SKIN CONDITIONING, SKIN CONDITIONING - EMOLLIENT

Aminopropyl Tocopheryl Phosphate is a stable, water-soluble pro-vitamin E that converts to active vitamin E in the skin. It acts as a potent antioxidant, protecting against free radicals and supporting skin health.

antioxidant skin conditioning

Science

Upon topical application, it is hydrolyzed by skin enzymes into alpha-tocopherol, the active form of Vitamin E. This delivers powerful antioxidant action, boosts collagen synthesis, and provides photoprotection against UVA damage.


Research

Medium confidence
Effective range 0.1–5%
Optimal

0.5%

Key findings

  1. 01 US Patent 10,265,264; Slideshare (Toco-APPA) on collagen synthesis and wrinkle treatment
  2. 02 The photoprotective properties of α-tocopherol phosphate against long-wave UVA1 (385 nm) radiation (NIH, 2014) in vitro study

Transparency

Not commonly dusted

No specific data on dusting thresholds or common dusting practices for this ingredient were found in the provided research.


The Formula

Solubility
Water
Optimal pH 6 – 8
0 7 14

Stability

Highly stable against oxidation, heat, and light compared to pure tocopherol. It remains stable in acid and alkaline conditions but can degrade or precipitate in extremely high pH environments above 10.0.

Conflicts

  • Strongly alkaline systems
  • Cationic surfactants

Safety

CIR Status
Safe as used
Max tested
5%
Sensitization risk Low

Reviewed as part of the broader Tocopherols and Tocotrienols group, the CIR Expert Panel deemed it safe for cosmetic use. Formulations should ensure no detectable hydroquinone impurities.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

This stable, water-soluble pro-vitamin E is a valuable antioxidant that enhances collagen synthesis and provides photoprotection for a wide range of skin types.


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