Science
Mechanism of Action
It acts as a non-selective phosphodiesterase (PDE) inhibitor, specifically PDE-3 and PDE-4, preventing cAMP breakdown within fat cells. This elevates cAMP, activating protein kinase A, which triggers hormone-sensitive lipase to hydrolyze triglycerides into free fatty acids and glycerol.
Research
Clinical Evidence
Medium confidence0.5%
Key findings
- 01 A 0.5% concentration applied five times weekly for five weeks was identified as potent for local fat reduction, though high-quality trials are limited.
- 02 Topical 2.0% in a cream base applied twice daily significantly reduced thigh circumference in female subjects.
- 03 Application of 10% ointment five times weekly for six weeks, combined with diet and walking, showed significant girth loss in overweight women.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
As a complex of theophylline and ethylenediamine, Aminophylline is sensitive to air (CO2), causing breakdown, theophylline precipitation, and yellowing. A stabilized base is crucial to prevent skin rashes.
Conflicts
- Acidic ingredients
- Carbon dioxide
- Oxidizing agents
- Strong acids
Safety
Safety Profile
While FDA-approved for systemic asthma treatment, Aminophylline is not officially reviewed by CIR for cosmetic use. Its ethylenediamine component is a known skin sensitizer and contact allergen, posing a significant risk.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Aminophylline demonstrates potential for targeted fat reduction but its significant risk of skin sensitization from ethylenediamine and unreviewed cosmetic safety status warrant caution.
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References
Sources