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AMINOMETHYL PROPANOL.

Valuable CAS 124-68-5 / BUFFERING

Aminomethyl Propanol is a potent pH adjuster and buffer, crucial for stabilizing formulations and optimizing the performance of pH-dependent ingredients. It is rated as safe for all skin types, with low irritancy and comedogenicity.

buffering pH adjustment emulsion stabilization

Science

This alkanolamine neutralizes acidic components like carbomers, forming stable salts to precisely regulate pH. This action ensures emulsion stability and maximizes the efficacy of other sensitive ingredients within a formula.


Research

High confidence
Effective range 0.1–7%
Optimal

N/A

Key findings

  1. 01 Human dermal irritation and sensitization tests at 7% concentration confirmed it is neither a primary irritant nor a sensitizer.
  2. 02 General use levels in cosmetics (typically <1%) are safe, with evaluations up to 10% demonstrating non-toxicity in practice.

Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH 7 – 12
0 7 14

Stability

Highly stable in alkaline pH environments (neat pH ~10.5), critical for consistent pH and stable neutralization of thickeners. Its volatility can also aid product drying time.

Synergies

  • Optimizes pH-dependent ingredients
  • Enhances emulsion stability

Conflicts

  • N-nitrosating agents
  • Isocyanates
  • Strong oxidizing agents
  • Acid halides
  • Anhydrides

Safety

CIR Status
Safe as used
Max tested
7%
Sensitization risk Low

Formulated up to 7%, it is deemed non-irritating and non-sensitizing. However, it must not be combined with N-nitrosating agents to prevent the formation of carcinogenic nitrosamines.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

Aminomethyl Propanol is a valuable component for ensuring formulation integrity and maximizing the efficacy of pH-sensitive ingredients in skincare.


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References