Science
Mechanism of Action
It acts as a precursor to Protoporphyrin IX (PpIX) by conjugating Aminolevulinic Acid with a tripeptide carrier for enhanced skin penetration. Upon exposure to blue or red light, it generates reactive oxygen species that target P. acnes bacteria and shrink sebaceous glands. It also exhibits high antioxidant capacity without light activation.
Research
Clinical Evidence
Medium confidence0.5%
Key findings
- 01 In vivo studies on ALA-peptides demonstrated significantly improved skin penetration and enhanced efficacy for photodynamic therapy of acne and sebum regulation, with reduced irritation compared to ALA-HCl.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Highly sensitive to light and oxygen; store in opaque, airtight containers. A slightly acidic environment (pH 4.5-6.0) helps prevent premature hydrolysis of the ALA-peptide bond.
Conflicts
- Strong oxidizing agents
- High pH environments (>7.0)
- Direct sunlight
Safety
Safety Profile
While constituent Tripeptide-7 is well-reviewed, this aminolevulinoyl derivative is a newer specialty ingredient. It is listed in the EU CosIng database as an antioxidant without specific restrictions.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Aminolevulinoyl Tripeptide-7 is a valuable active ingredient, uniquely targeting acne and sebum through light-activated mechanisms while offering broad-spectrum antioxidant protection.
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References
Sources