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AMINOLEVULINOYL TRIPEPTIDE-63.

Valuable / ANTI-SEBUM, ANTIOXIDANT, HAIR CONDITIONING, SKIN PROTECTING

This advanced peptide acts as a prodrug, delivering 5-aminolevulinic acid directly to target skin cells and hair follicles. It effectively addresses concerns like acne, excess sebum, and hair thinning through precise light-activated mechanisms.

anti-sebum antioxidant hair conditioning skin protecting

Science

It functions as a prodrug, accumulating in sebaceous glands and hair follicles where it metabolizes into Protoporphyrin IX (PpIX). When exposed to specific light, PpIX generates reactive oxygen species, reducing sebocyte activity, exhibiting antimicrobial effects on P. acnes, and stimulating hair growth.


Research

Medium confidence
Effective range N/A
Optimal

5%


Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH 5 – 7.4
0 7 14

Stability

Stable at physiological pH and in aqueous solutions. The peptide conjugate offers improved stability over its precursor derivatives.

Conflicts

  • Strong oxidizing agents
  • Chelating agents
  • Strong acids/bases

Safety

CIR Status
Not reviewed
Max tested
5%
Sensitization risk Low

Safety is generally high due to its localized action at the application site, exhibiting better skin confinement and less systemic diffusion compared to pure 5-ALA. Minimal 'dark' toxicity has been reported.


Your Skin

Yes Normal
No Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

Aminolevulinoyl Tripeptide-63 is a valuable ingredient for targeted acne and hair loss solutions, offering effective, localized action with a favorable safety profile.


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