Science
Mechanism of Action
This nucleophilic hydrazine compound traps reactive dicarbonyl intermediates, preventing AGE formation and subsequent cross-linking of collagen and elastin. It also selectively inhibits iNOS, offering anti-inflammatory benefits to the skin.
Research
Clinical Evidence
Medium confidence1%
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Highly unstable when heated above 50°C, requiring fresh preparation or low-temperature storage. Aqueous solutions decompose gradually.
Conflicts
- Strong acids
- Strong oxidizing agents
- Nitrosating agents
Safety
Safety Profile
This ingredient is not yet a standard cosmetic component reviewed by the CIR. ECHA classifies it as a potential skin sensitizer and irritant, although topical use below 1% is generally considered non-toxic in preliminary models.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While promising for anti-glycation and skin health at low concentrations, its unreviewed cosmetic status and potential for irritation warrant caution.
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References
Sources