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Moumoujus

AMINOBUTYROYL TRIPEPTIDE-1.

Essential / ANTIOXIDANT, SKIN PROTECTING

A powerful signaling peptide, Aminobutyroyl Tripeptide-1 stimulates collagen and elastin production while its derivatives effectively reduce muscle contractions, smoothing expression lines. It’s a multi-functional ingredient for comprehensive anti-aging benefits.

Summary

cell-communicating ingredient skin conditioning

Science

Mechanism of Action

This tripeptide acts as a signal peptide, mimicking collagen degradation to trigger fibroblast synthesis of collagen, elastin, and GAGs. Certain derivatives also function as neuromuscular antagonists, relaxing facial muscles to reduce the appearance of wrinkles.

Research

Clinical Evidence

High confidence
Effective range 3–5%
Optimal

4%

Key findings

  1. 01 A 28-day study demonstrated 4.0% Syn-Ake significantly reduced forehead wrinkles and crow's feet by inhibiting muscle contractions.
  2. 02 In-vivo trials for 3.0% - 5.0% Matrixyl 3000 (containing Palmitoyl Tripeptide-1) showed a 39.4% reduction in deep wrinkle surface area after 60 days.
  3. 03 In-vitro studies confirm Tripeptide-1 stimulates collagen, elastin, and fibronectin synthesis at nanomolar concentrations (less than 0.01%).

Transparency

Dusting Analysis

Commonly dusted

While pure Aminobutyroyl Tripeptide-1 is effective in vitro at extremely low concentrations, clinically proven derivatives for wrinkle reduction are used at 3-5%. Products claiming this ingredient without specifying a derivative or adequate concentration may be underdosed.

The Formula

Formulation

Solubility
Water
Optimal pH 3.5 – 6.5
0 7 14

Stability

Peptides are prone to hydrolysis; stability is best between pH 4.0-6.0 and by avoiding extreme heat. Conjugation with palmitic acid can enhance skin penetration and oil solubility.

Synergies

  • Antioxidants
  • Hyaluronic Acid
  • Retinoids

Conflicts

  • Strong oxidizing agents
  • High concentrations of AHAs/BHAs
  • Strong electrolytes

Safety

Safety Profile

CIR Status
Safe as used
Max tested
0.002%
Sensitization risk Low

The CIR Expert Panel (2014) found Tripeptide-1 and its derivatives safe at typical use concentrations. It is non-toxic, non-sensitizing, and non-irritating.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Essential

Aminobutyroyl Tripeptide-1 and its clinically effective derivatives are essential for their potent ability to stimulate collagen and reduce expression lines, making it a cornerstone for comprehensive anti-aging strategies.

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