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AMIDINO BETA-ALANINE.

Valuable CAS 353-09-3 / SKIN CONDITIONING

Amidino Beta-Alanine is a multi-functional amino acid derivative that supports skin vitality and microcirculation. It acts as a humectant and skin conditioner, making it a versatile ingredient for various skin concerns.

skin conditioning humectant

Science

This creatine analog supports cellular turnover and microcirculation, potentially enhancing overall skin health. It is proposed to offer a 'stress-relieving' effect on skin by gently reducing muscular tension at the surface, which may help smooth the appearance of fine lines.


Research

Medium confidence
Effective range 1–5%
Optimal

N/A

Key findings

  1. 01 Topical application at 1-5% has been observed to stimulate human endothelial cell growth, suggesting benefits for angiogenesis and wound healing.

Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH 6 – 7.5
0 7 14

Stability

Highly water soluble (approx. 100 mg/mL), it is a zwitterionic molecule most stable near neutral pH. Avoid extreme acidic conditions which can degrade its guanidino group.

Conflicts

  • Strong oxidizing agents
  • Strong acids
  • Anionic surfactants (due to potential complex formation with its cationic amidino group)

Safety

CIR Status
Not reviewed
Max tested
5%
Sensitization risk Low

While not formally reviewed by the CIR, it is used in commercial skincare up to 5%. In pure form, safety data sheets identify it as a potential skin and eye irritant (GHS Category 2).


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

Amidino Beta-Alanine is a valuable ingredient for anti-aging and revitalizing formulas, offering cellular support, microcirculation benefits, and potential fine line smoothing with broad skin compatibility.


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