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ALUMINUM ZIRCONIUM PENTACHLOROHYDREX GLY.

Valuable CAS 125913-22-6 / ANTIPERSPIRANT, ASTRINGENT, DEODORANT

ALUMINUM ZIRCONIUM PENTACHLOROHYDREX GLY is an FDA-approved antiperspirant agent. It effectively reduces perspiration by creating a temporary physical barrier within sweat ducts, making it valuable for clinical strength sweat control.

antiperspirant astringent deodorant

Science

This complex forms a colloidal polymer 'gel plug' upon reacting with sweat within eccrine gland ducts, physically blocking perspiration. These plugs are naturally shed over time through the skin's normal keratinization process.


Research

High confidence
Effective range N/A
Optimal

20%

Key findings

  1. 01 Typical sweat reduction at 20% concentration ranges from 20% to 60%, aligning with FDA-allowed maximums for anhydrous complexes.
  2. 02 Average dermal absorption of aluminum through the skin is notably low, approximately 0.012%, based on studies of similar aluminum complexes.

Transparency

Not commonly dusted

The Formula

Solubility
Water
Optimal pH 3 – 5
0 7 14

Stability

Optimal stability and efficacy are observed in acidic environments (pH 3.0-5.0), decreasing at higher pH. Glycine is added to stabilize zirconium and prevent premature precipitation; avoid heating above 80°C.

Conflicts

  • Strong bases
  • Anionic surfactants
  • Soap-based emulsifiers
  • Phosphate-containing ingredients

Safety

CIR Status
Not reviewed
Max tested
20%
Sensitization risk Low

Safety is primarily regulated by the FDA OTC Antiperspirant Monograph in the US. The SCCS (EU) deems it safe in non-spray formulations up to maximum levels but restricts its use in sprayable products.


Your Skin

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Valuable

This active ingredient is highly effective as an antiperspirant, clinically proven to reduce sweat, and is well-tolerated by most skin types.


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