Science
Mechanism of Action
It forms a temporary colloidal gel plug within eccrine sweat gland ducts by reacting with proteins and mucopolysaccharides, physically blocking sweat. Glycine stabilizes the complex and optimizes efficacy by maintaining an acidic pH.
Research
Clinical Evidence
High confidence20%
Key findings
- 01 At 20%, sweat production is reduced by 20% to 60%, aligning with FDA's maximum OTC concentration.
- 02 Formulations between 13% and 16.4% are typically effective for axillary wetness reduction.
Transparency
Dusting Analysis
This ingredient is an active antiperspirant, requiring higher concentrations to exert its intended occlusive effect on sweat ducts, not typically used in micro-dosing.
The Formula
Formulation
Stability
Stable in anhydrous systems and acidic aqueous solutions. Glycine or betaine are often used to prevent polymerization and maintain stability in aqueous formulations.
Conflicts
- Strong bases
- Anionic surfactants
- Soap-based emulsifiers
- Certain phosphates
Safety
Safety Profile
Regulated by the FDA as an OTC drug active in the US. The SCCS (EU) considers aluminum salts safe in antiperspirants, restricting it to 20% (as anhydrous aluminum zirconium chlorohydrate).
Your Skin
Skin Compatibility
Our Assessment
Verdict
A highly effective and well-regulated active ingredient, crucial for formulations targeting significant sweat reduction and offering astringent benefits.
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References
Sources