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ALUMINUM SESQUICHLOROHYDREX PG.

Valuable CAS 245090-60-2 / ANTIPERSPIRANT, ASTRINGENT, DEODORANT

ALUMINUM SESQUICHLOROHYDREX PG is a highly effective antiperspirant agent, typically supplied as a 50% aqueous solution. It reduces sweat production and offers beneficial astringent properties to the skin.

Summary

antiperspirant astringent

Science

Mechanism of Action

This ingredient forms temporary, superficial gel-like plugs within sweat ducts, effectively obstructing sweat flow to the skin surface. Its astringent action also leads to local protein precipitation and cell contraction, which helps tighten pores.

Research

Clinical Evidence

High confidence
Effective range 20–25%
Optimal

20%

Key findings

  1. 01 A randomized controlled trial demonstrated 20% aluminum sesquichlorohydrate provided efficacy comparable to 20% aluminum chloride for axillary hyperhidrosis, with superior safety and less irritation.
  2. 02 FDA OTC monograph guidelines identify 25% as the maximum safe and effective concentration for antiperspirant drug products.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 3 – 5
0 7 14

Stability

Stability is highly pH-dependent; at pH values above 5.0-6.0, the ingredient hydrolyzes and precipitates as insoluble aluminum hydroxide.

Conflicts

  • Bases (amines, inorganic hydroxides)
  • Phosphate buffers
  • Citrate buffers
  • Strong oxidizing agents
  • Certain metals (aluminum, zinc, tin)

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
25%
Sensitization risk Low

The CIR typically defers evaluation to the FDA's assessment as an OTC drug. EU Regulation 1223/2009 considers it safe up to 20% (as aluminum chlorohydrate equivalent), with SCCS confirming it is non-sensitizing and lacks systemic toxicity via dermal application.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

ALUMINUM SESQUICHLOROHYDREX PG is a valuable, well-tolerated antiperspirant active, offering proven efficacy and low irritation across all skin types for sweat reduction and pore tightening.

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