Science
Mechanism of Action
This compound forms temporary gel-like plugs within the distal sweat gland ducts by reacting with sweat electrolytes and mucopolysaccharides. This physical obstruction prevents sweat from reaching the skin surface, with the plugs naturally shedding during epidermal renewal.
Research
Clinical Evidence
High confidence20%
Key findings
- 01 20% concentration demonstrated efficacy comparable to 20% aluminum chloride for primary axillary hyperhidrosis, with a superior safety profile (less itching/irritation).
- 02 20% in topical foam form proved effective and well-tolerated for both axillary and palmar primary hyperhidrosis.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Highly soluble in water and ethanol (up to 55%), but insoluble in oils. Anhydrous formulations, often utilizing cyclomethicone, are common to prevent premature hydrolysis.
Conflicts
- Iron
- Brass
- Copper
- Aluminum metal
- Mild steel (corrosive to these metals)
- Strongly alkaline ingredients (causes precipitation)
Safety
Safety Profile
The FDA allows up to 25% (anhydrous) in OTC antiperspirants, with extremely low dermal penetration (~0.00052%). SCCS (2024) considers aluminum compounds safe in non-sprayable products up to 25% and in sprayables meeting particle size constraints.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Aluminum Sesquichlorohydrate is a valuable ingredient for effective sweat reduction, offering high efficacy with a low irritation potential suitable for various skin types.
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References
Sources