Science
Mechanism of Action
It forms temporary gel-like plugs within eccrine sweat ducts by precipitating with sweat components at the skin's surface. This physical obstruction prevents sweat from reaching the skin, with plugs naturally shedding via keratinization.
Research
Clinical Evidence
High confidence20%
Key findings
- 01 Indicated as an effective concentration for over-the-counter antiperspirant use to reduce perspiration (FDA OTC Monograph).
- 02 Utilized in clinical strength formulations to provide sweat protection with lower irritation potential compared to aluminum chloride (Certain Dri Clinical Data / MDPI 2023).
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Most stable in acidic aqueous solutions; functionality decreases at high pH. Often formulated with glycols for enhanced stability and skin feel.
Synergies
- Glycols (e.g., Propylene Glycol) for stability and skin feel
Conflicts
- Alkaline ingredients
- Anionic surfactants
- Strong oxidizers
- High pH environments
Safety
Safety Profile
CIR defers to FDA, which regulates it as an OTC drug active permitting up to 25% (anhydrous). SCCS (2022/2023) considers aluminum salts safe at specified levels, with negligible dermal penetration (approx. 0.00052%).
Your Skin
Skin Compatibility
Our Assessment
Verdict
An essential and highly effective ingredient, proven safe and well-tolerated for reducing perspiration in precision skincare applications up to 25%.
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