Science
Mechanism of Action
This ingredient forms a physical gel matrix or plug within the distal sweat gland ducts. Metal ions precipitate with mucopolysaccharides, causing epithelial cell damage that obstructs sweat flow.
Research
Clinical Evidence
High confidence15%
Key findings
- 01 Clinical trials demonstrate that 15% concentrations are as effective as 20% for axillary hyperhidrosis, with significantly better patient tolerability and reduced irritation.
- 02 Iontophoresis of 1% aluminum chloride hexahydrate induced significant hypohidrosis lasting 4 weeks without reported side effects.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Highly hygroscopic, it reacts with water to form hydrochloric acid, a known irritant. It remains stable in anhydrous ethanol or acidic aqueous solutions, but hydrolysis increases above pH 4.0.
Conflicts
- Bases
- Strong oxidizers
- Alkali metals
- Water (reacts exothermically in anhydrous form)
- Most metals (corrosive)
Safety
Safety Profile
The FDA OTC monograph permits up to 15% (as hexahydrate) in non-aerosol solutions. While SCCS deems aluminum compounds safe at specified levels, concentrated aluminum chloride is a known skin irritant and potential allergen.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Aluminum Chloride is a highly effective ingredient for managing hyperhidrosis, yet its potential for high irritancy necessitates careful formulation and use, especially for sensitive skin types.
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References
Sources